Multiple Sclerosis

Approaches and Strategies

Multiple Sclerosis (MS) is a neurological disorder affecting the Central Nervous System.  MS patients have a loss of the myelin sheath that surrounds nerve cells.  This demyelination occurs in the white matter of the brain, spinal cord, and in the optic nerves (1).  It is this change to the myelin that causes the signs and symptoms such as weakness, numbness, loss of balance, double vision, or urinary urgency or hesitancy.  MS is diagnosed only when there are two or more different regions of the central white matter shown to be affected at different times.

The illness may take different forms- usually there is a long interval of months or years after the first episode before symptoms return.  This is known as a relapsing-remitting form of the disease.  In other patients, there is a steady deterioration, this is a secondary progressive illness.  In fewer patients, the symptoms develop steadily and disability develops at an earlier stage.  This is a primary progressive form of the illness (1).

Western medicine has various drugs that are designed to slow down the progression of this disease, but there are other interventions an MS patient may take.  These complementary options can be used alongside any standard treatment already in use, and are regarded as healthy and safe practices for anyone.  Two valuable options in particular are nutrition and acupuncture.

Acupuncture for Multiple Sclerosis

Acupuncture has a long history of treating many health disorders.  Acupuncture is most commonly done by inserting thin, sterile needles onto certain acu-points located all along the body, and this is a time honored system to treat many diseases.  For neurological illnesses such as Multiple Sclerosis however, a different and more effective method can be used-scalp acupuncture.  In scalp acupuncture, the needles are placed just under the skin on the head in order to stimulate certain representative areas of the cerebral cortex.  This helps allow the patient’s body to gain control over such issues as numbness, pain, spasms, weakness, and balance problems.  Scalp acupuncture has been shown in clinics to be the most successful method for treating problems associated with MS (2).  Another advantage of scalp acupuncture for disorders of a neurological nature is that the patient will usually know if the treatment is working for them within two or three sessions.

Nutrition and Multiple Sclerosis

Another very important aspect of care for the MS patient is nutrition.  There are certain supplements that have been researched and show promise in the treatment of neurological diseases and MS.  Most notably these are essential fatty acids and antioxidants.  It has been observed that many MS patients have a deficiency of fatty acids, especially linoleic acid.  Linoleic acid is found in nuts, seeds, whole grains, fruits and vegetables, and has properties that reduce inflammation.  There are some studies that show that individuals who have MS experience less severity and duration of relapses when taking linoleic acid (3).  A useful dose of linoleic acid is had by taking one tablespoon of fresh flax oil with a meal, once per day.  Other people with MS find that they do better with oils such as borage seed oil or evening primrose oil, which have GLA, another important fatty acid with anti-inflammatory properties.  As with any oil, for best health benefits try to use recently cold pressed oil, and keep it cool and shielded from light.

Other beneficial fatty acids are the omega-3 fats, most notably found in cold water fish.  One study in the Journal of Autoimmune Disorders found that omega-3 fatty acids are capable of preventing a disruption in the blood brain barrier, thus keeping inflammatory agents out of the central nervous system(4).  Remember that MS is believed to be caused, at least in part, by inflammation in the central nervous system.  Another study states that omega-3’s are helpful to prevent neurological disorders (5).  For these and many other health benefits, omega-3 fatty acids are a great addition to the diet of those controlling MS.

There are other dietary factors a person with MS should consider as well.  First is that MS patients seem to have a higher rate of sensitivity to gluten, the protein found in wheat and many grains. A gluten free diet may be helpful, particularly if the patient tests positive for antibodies to gluten.  Secondly is that MS patients also tend to have more chronic infections of Candida Albicans, a yeast overgrowth.  Dietary modification and treatment for this may be helpful as well.

Chinese Dietary Therapy and Multiple Sclerosis

In Traditional Chinese Medicine (TCM), it is said the nerves are governed by the liver.  In TCM, foods which nourish the liver are leafy green vegetables, mung beans, millet, seaweed, wheat grass, chlorella, and organic animal liver.  Interestingly, today we know these foods happen to be sources of superoxide dismutase (SOD), the enzyme that controls free radicals and reduces inflammation (6).  Remember that free radical damage seems to play a role in MS development.  So whether you like traditional views of therapeutic foods, or modern research on micronutrients, the good news is they ultimately seem to agree.  In any case the foods listed above and all other whole fresh vegetables are helpful for people who happen to have MS.

Also within TCM, the signs and symptoms of paralysis and spasms are typically diagnosed as “wind”.  While this may seem like a simplified diagnosis, many controlling and contributing factors are recognized for each diagnosis in Chinese medicine.  Methods of controlling “wind” are herbal medicine, diet, and acupuncture.  Foods that TCM says reduce” wind” are celery, basil, sage, fennel, ginger, anise, oats, pine nut and coconut (6).  Foods that may contribute to “wind” are eggs and crab, and should be limited in cases with spasms or paralysis.

The person with MS has challenges, but hopefully also sees these strategies and tools as ways to help their health.  With the right balance of these methods alongside their conventional therapy, they should be more empowered to maintain their health and lifestyle.

Thank you for your interest in this article. If you have any questions, please feel free to contact me.

Stephen Dell-Jones, AP, DOM

References:

1)     McPhee, Stephen; Papadakis,Maxine; Rabom, Michael; 2012 Current Medical Diagnosis and Treatment. Fifty First edition. McGraw Hill Medical, New York pg.983-985.

2)     Hao, Jason; Hao, Linda Lingzhi; 2008, Treatment of Multiple Sclerosis by Scalp Acupuncture, Acupuncture Today, 2008, 9(4).

3)     Royal College of Physicians (UK) 2004, Multiple Sclerosis-National Clinical Guideline for Diagnosis and Management in Primary and Secondary care.

4)     Shinto, L.; Marracci,G; Bumgarner,L.; Yadam,V; 2011 The effects of omega 3 fatty acids on matrix metalloproteinase-9 production and cell migration in human immune cells: implications for multiple sclerosis. Journal of Autoimmune Disorders 2011 10(4061).

5)     Mazza,M; Pomponi,M; Janiri,L; Bria,P; Mazza,S; Omega 3 fatty acids and antioxidants in neurological and psychiatric disease. 2007 Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2007. 31 (1) 12-26.

Pitchford, Paul, 2002, Healing with Whole Foods, Third Edition, North Atlantic Books, Berkeley California pgs.170-174, 328-329.

Bone Health: The Other Part of the Equation

An overview of contributing factors to the prevention and treatment of Osteopenia and Osteoporosis, by Stephen Dell-Jones, DOM.

There is a major public health problem facing Americans, one that can result in a complete decline in an individual’s health, as well as hospitalization, need for long term care, and loss of independence.  The problem is osteoporosis and osteopenia.  While everyone has become aware of the meaning of osteoporosis, osteopenia refers to a condition of low bone mineral density, not yet low enough to be labeled osteoporosis.  Both are highly affected by diet, lifestyle, supplements and exercise.  We will review the prevalence of osteoporosis, consequences from the disease, current methods of prevention, and other possibilities that can be employed.

From 2005 to 2006, 49% of women over 50 years old had osteopenia, and 10% had osteoporosis at the neck of the femur bone (Looker,et al., 2010). Thirty percent of men over 50 had osteopenia, and 2% had osteoporosis at the neck of the femur (Looker et al., 2010). It is important to realize that the most common osteoporosis related fracture sites are the vertebrae (compression fracture), hip (femur neck), and wrist (Kotz et al., 2004). The overall lifetime risk for a woman having an osteoporosis related fracture is 39.7% (Kotz et al., 2004). If these numbers are not sobering enough by themselves, consider that a bone fracture in an older person will cause hospitalization, and may possibly require long term care.  Many elderly people never return to an independent life after an event like this.  The time to prepare for this type of problem is not when you are elderly, it is now.  Let us now look at not only current recommendations but also newer research on prevention of bone loss.

When we think of bone health, the first nutrients to come to mind are calcium and vitamin D.  Bones are made with calcium, and we also need vitamin D to help us absorb calcium. These two nutrients have been of primary concern when dealing with bone health.  The National Osteoporosis Foundation recommends 1200 mg of Calcium daily for men over 71 years old and women over 50.  For men under 71 and women under 50 it is 1000 mg per day.  They also recommend 800 IU of vitamin D daily for men and women over 50, and 400-800 IU for men and women under 50.  Two researchers wrote in the Journal of Current Osteoporosis Reports that having good nutritional status, consuming calcium and vitamin D, and avoiding excess alcohol is associated with better bone health (Levis & Lagori, 2012). Avoiding excess sodium is also beneficial  (Miggiano & Gagliard, 2005).  These are the main standard recommendations for prevention and management of osteoporosis.  Certainly when these are not enough, there are medications that are often prescribed.  However, medications commonly have side effects, and osteoporosis drugs are no exception.  Using certain supplements could be a healthier alternative.

One such supplement is menaquinone, or vitamin K2.  Vitamin K2 is found in very small amounts in meats, dairy, and in larger amounts in some fermented foods like natto (fermented soy). Also, our intestinal bacteria produce vitamin K.  According to a research study on vitamin K2, adding it to a dietary program that already included vitamin D and calcium reduced the lifetime probability of a fracture by another 25% (Gajic et al. 2012).  Another study found that adding K2 to a diet already supplemented with calcium and vitamin D added more bone mass density to the lumbar vertebrae compared to subjects who took the same level of calcium and vitamin D alone (Kanellakis et al., 2012).  Remember that one of the major three types of osteoporosis related fractures is compression fractures of the vertebrae.  The study concluded that vitamin K2 created a more favorable bone metabolism (Kanellakis et al., 2012). Likewise, the Journal of Environmental and Public Health included a study with vitamin K2, which found that subjects who were either of normal bone density or already osteoporotic, and took a regimen of vitamin D3, K2, strontium, magnesium, and DHA (omega three fatty acid), had improved bone mineral density.  The interesting fact here is that the results were as good, or better, than taking bisphophonates, a commonly used osteoporosis drug (Genuis & Bouchard, 2012).  Also of note is that the protocol worked well for patients who had previously had poor outcomes with the bisphosphonates.  These findings suggest that Vitamin K2 should be a part of an osteoporosis prevention or treatment plan.  The amounts used were approximately 180 ug (micrograms).  It should be noted that vitamin K contributes to blood clotting, so those on a blood thinner should inform their prescribing physician of any changes in diet and supplements.

Another newer consideration regarding bone health  is how the collagen in bone affects its health, strength and resistance to fracture.  Bones are actually 30% collagen, a very important structural protein in the body.  In bone, the collagen forms a framework for the attachment of calcium and other minerals (Brylka et al., 2010).  The organized arrangement of mineral crystals depends on the collagen, and without adequate collagen, there will be less place for calcium to adhere to, thus lower bone mass overall.  It has always been known that bones are not made of minerals alone, but now the importance of the collagen content and quality is being more closely evaluated.  According to the Journal of Osteoporosis International, bone strength is affected not just by mineral density, but by geometry and shape of bone, microarchitectural factors in the bone, and the collagen (Viquet-Carrin et al., 2006). Another study states that the loss of collagen from the bone is highly correlated with bones being more susceptible to breaking from stresses (Nyman & Makowski , 2012). This would seem to be at least partially because it is the collagen that provides flexibility to the bones.  Bones are not completely hard, rigid structures but instead flex slightly.  Collagen provides both flexibility and frame for mineral  bonding.  Researchers have shown that the collagen molecules not only attract calcium phosphate to them, but also help arrange the calcium into parallel sheets (Brylka et al., 2010) This is how bones form minerals into a specialized lattice for strength.  Clearly, collagen is important  and it would be beneficial to minimize collagen loss. However, collagen loss begins sooner than mineral loss, as early as age 21.  Also, until recently, there was no known way to prevent or reverse this loss because collagen is a protein and merely ingesting it would cause it to be broken down.  What is needed is a method of stimulating our own production of collagen.  There is a naturally occurring molecule that was believed to do just that, orthosilicic acid (OSA). The problem was that it was unstable and would be of no value to us if ingested.  Now, however, OSA can be stabilized by choline, a natural compound needed to build cellular membranes.  Choline-stabilized OSA, or ch-OSA, is showing good results in increasing bone collagen and thereby overall bone mass (Specter et al., 2005; Specter et al. 2008 ).

In conclusion, it is important to maintain our bone health as much as possible, especially for women who are more at risk as shown above. Using calcium and vitamin D is paramount, but the whole picture also involves vitamin K2, a ch-OSA collagen generator, a diet that promotes good nutrition status, regular weight bearing exercise, moderate exposure to sunlight for vitamin D, smoking cessation, and reduction of alcohol, sodium, caffeine and soda drinks.

Thank you very much for your interest in my article.  If you have any questions, by all means feel free to contact me.

Stephen Dell-Jones Dipl. Ac, DOM

Sources:

Gajic-Veljanoski, Bayourni, Tomlinson, Khan, and Cheung  (2012). Vitamin K Supplementation for the primary prevention of osteoporotic fractures: is it cost effective and is future research warranted?  Osteoporosis International, 23(11), 2881-92.

Gennis, Bouchard (2012). Combination of micronutrients for bone study: bone density after micronutrient intervention.  Journal of Environmental and Public Health, 2012:354151.

Kanellakis, Moschonis, Fento, Schaafsma, van den Huevel, Papaioannou, Lyritis, Manios (2012). Changes in Parameters of bone Metabolism in postmenoapusal women following a 12 month intervention period using dairy products enriched with Calcium, Vitamin D, and phylloquinone(K1) or menaquinone-7(K2): the postmenoapusal Health Study II. Calcified Tissue International, 90(4), 251-62.

Krista Kotz, Stephanie Deleger, Richard Cohen, Alisa Kamigaki, John Kurata (2004). Osteoporosis and health related quality of life outcomes in the Alameda county study population. Preventing Chronic Disease. 1(1)

Anne Looker, Joseph Melton, Tamara Harris, Lori Borrund, John Shepherd (2010). Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III. Journal of Bone and Mineral Research. 25(1)p. 64-71.

Miggiano and Gagliardi (2005). Diet, Nutrition and Bone Health. Clinica Terapeutica. 156(1-2) p. 47-56.

Nudelman, Dieterse, George, Bomans, Friedrich, Brylka, Hilbers, deWith, Sommerdijk (2010). The role of collagen in bone apatite formation in the presence of hydroxy apatite nucleation inhibitors. Nature Materials, 9,1004-1009.

Nyman, Makowski (2012). The contribution of the extracellular matrix to the fracture resistance of bones. Current Osteoporosis Reports, 10(2) 169-177.

Silvina, Levis, Violet, and Lagori (2012). The role of diet in Osteoporosis Prevention and Management. Current Osteoporosis Reports. 10(4) pg 296-302.

Specter et al. (2005). Effect on bone turnover and bone mineral density of low dose oral silicon as an adjunct to calcium and D3 in a randomized, placebo controlled trial. Journal of Bone and Mineral Research, 20(1).

Specter et al. (2008). Choline stabilized orthosilicic acid supplementation as an adjunct to  calcium and D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo controlled trial. Musculoskeletal Disorders, 9(85)

Viquet-Carrin, Garnero, Delmas (2006). The role of collagen in Bone Strength. Osteoporosis International, 17(3) 319-36.

Cold & Flu Season Approaches…

It is again that time of year when some people may prepare themselves for colds and flu. Everyone is very aware of the standard flu shot, but how aware are we of the details?

The effectiveness of the flu shot does not extend beyond three or four strains of virus that are expected to be common in the season. This may be why the vaccination sometimes has no helpful effect. Of even more concern should be some of the substances used in the flu vaccine, such as formaldehyde, mercury, and polysorbate 80 (PS80). According to the US Environmental Protection Agency (EPA), mercury can harm the brain, heart, kidneys, lungs, and immune system (EPA.gov, 2012). PS80 has been associated with Guillain-Barre Syndrome (GBS). “On rare occasion they may develop GBS in the days or weeks after vaccination” (CDC.gov, 2012). GBS is a disorder that causes the immune system to attack its own nerve cells, possibly resulting in paralysis; these effects could last a few weeks or are sometimes permanent.

This season, one may want to consider a safer, more natural way to protect themselves from the flu. One such method is the use of a homeopathic preparation that is specifically designed to stimulate the body’s own defense mechanisms on a complete systemic level. Just a few convenient daily oral dosages of “Immunexx” can strengthen the defenses your body normally has against colds and flu.

The advantages?    First, no potentially   hazardous components. Second, activation of defense against a much wider spectrum of germs (viruses, bacteria, etc.). Third, enhancement of your health instead of gradual decline from accumulation of contaminants.

Contact me to pick up your flu protection today.

Not all Vitamin E is equal

There has been conflicting evidence about the protective effects of vitamin E on cancer. One reason for this seems to be that while vitamin E may act as an antioxidant and reduce mutations that lead to cancer, for already formed cancer cells vitamin E may confer its antioxidant activity to the cancer cells and actually protect the cancer. And some studies have shown that vitamin E supplementation was not effective in the prevention of cancer. A potential problem with these studies, however, is that they were evaluating dl-alpha tocopherol acetate, a synthetic form of vitamin E. Not all forms of vitamin E interact the same way in the body. Some researchers believe that the synthetic form may slow down the antioxidant function by taking binding sites that would have been available for natural E, d-alpha tocopherol.

However, a form of vitamin E known as vitamin E succinate (alpha tocopheryl succinate) actually targets cancer cells with its own special attack. It triggers the production of free radicals inside cancer cells, triggering cell death, while being non toxic to healthy cells. Clinical trials are showing this advantage of succinate that other vitamin E forms did not seem to have. Vitamin E succinate does not have antioxidant activity of its own, but during the digestive process, some succinate is enzymatically converted to d-alpha tocopherol, which does have antioxidant activity.

So if you are going to supplement with vitamin E, you may want to consider using the succinate form. 400 IU is currently being recommended in light of these newer insights on vitamin E.

summarized from “Vitamin E Succinate continues to show impressive Anti-Cancer properties”, Dr. James Meschino, Acupuncture Today, March 2016.